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The Resource Bioengineering in Cell and Tissue Research

Bioengineering in Cell and Tissue Research

Label
Bioengineering in Cell and Tissue Research
Title
Bioengineering in Cell and Tissue Research
Creator
Contributor
Subject
Language
eng
Summary
The idea of publishing this book on "Bioengineering in Cell and Tissue Research" was originated by Gerhard M. Artmann, with the goal of writing about our dreams and making the reader dream with the authors and be fascinated. The book is meant to have life and spirit, and to become a pioneer in technology and sciences, es- cially the life science. The chapters in this book are written by excellent scientists on advanced, frontier technology and address scienti?c questions that need consid- able thinking in terms of engineering. The aims are to provide the readers, including students, faculty, and all scientists working in academia and industry, new infor- tion on bioengineering in cell and tissue research to enhance their understanding and innovation. This book is composed of six sections that cover a broad hierarchy from genes to the universe. These sections are Genes, Genome and Information Network; Cell and Tissue Imaging; Regenerative Medicine and Nanoengineering; Mechanics of Soft Tissues, Fluids and Molecules; Bioengineering in Clinical Applications; and Plant and Microbial Bioengineering
Cataloging source
MiAaPQ
Dewey number
620
LC call number
  • TA1-2040
  • TA1-2040
Literary form
non fiction
Nature of contents
dictionaries
Label
Bioengineering in Cell and Tissue Research
Instantiates
Publication
Copyright
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • CONTENTS -- Part I Genes, Genome and Information Network -- 1 Reporter Genes in Cell Based ultra High Throughput Screening -- 1.1 Introduction -- 1.2 From Gene to Target -- 1.3 Screening Assay Classes -- 1.4 Reporter Gene Classes -- 1.5 Flash-Light Reporter Genes -- 1.6 Glow-Light Reporter Genes -- 1.7 Coelenterazine Dependent Luciferases -- 1.8 Luciferin Dependent Luciferases -- 1.9 Non-Luciferase Glow-Light Reporter Genes -- 1.10 Fluorescent Proteins -- 1.11 Cell Based Assay Formats in ultra High Throughput Screening (uHTS) -- 1.12 Reporter Genes in uHTS -- 1.13 Photoprotein Readouts and Cell-Based Assay Development -- 1.14 Multiplexing Reporter Gene Readouts -- 1.15 Ultra High Throughput Screening -- References -- 2 Gene Arrays for Gene Discovery -- 2.1 Introduction -- 2.2 Data Processing -- 2.3 Gene Discovery by Gene Clustering -- 2.4 TGF-β1 Signaling in Dendritic Cells Assessed by Gene Expression Profiling -- 2.5 Conclusions -- References -- 3 Physical Modulation of Cellular Information Networks -- 3.1 Introduction -- 3.2 Cellular Responses to Physical Stimulation -- 3.3 Electrically Controlled Proliferation Under Constant Potential Application -- 3.4 Modulated Proliferation Under Extreme Hydrostatic Pressure -- 3.5 Electrically Modulated Gene Expression Under Alternative Potential Application -- 3.6 Cellular Engineering to Enhance Responses to Physical Stimulation -- 3.7 Concluding Remarks -- References -- Part II Cell and Tissue Imaging -- 4 Fluorescence Live-Cell Imaging: Principles and Applications in Mechanobiology -- 4.1 Introduction -- 4.2 Fluorescence Proteins -- 4.3 Fluorescence Microscopy -- 4.4 Applications in Mechanobiology -- 4.5 Perspective in Cardiovascular Physiology and Diseases -- References -- 5 Optical Coherence Tomography (OCT) - An Emerging Technology for Three-Dimensional Imaging of Biological Tissues
  • 5.1 Introduction -- 5.2 Optical Coherence Tomography (OCT) -- 5.3 Applications in Tissue Engineering -- 5.4 Conclusion -- References -- 6 Ultrasonic Strain Imaging and Reconstructive Elastography for Biological Tissue -- 6.1 Introduction -- 6.2 Ultrasound Elastography -- 6.3 Reconstructive Ultrasound Elastography -- 6.4 Medical Results of Elastography -- 6.5 Results of an Intravascular Ultrasound Study -- 6.6 Summary and Conclusion -- References -- Part III Regenerative Medicine and Nanoengineering -- 7 Aspects of Embryonic Stem Cell Derived Somatic Cell Therapy of Degenerative Diseases -- 7.1 Introduction -- 7.2 Rationale for the Cardiac Tissue Engineering -- 7.3 Embryonic Stem Cells as an Unlimited Source for Cardiomyocytes -- 7.4 Therapeutical Cloning of Embryonic Stem Cells -- 7.5 Stem Cell Derived Cardiomyocytes -- 7.6 Cardiac Tissue Slices -- 7.7 Bioartificial Heart Tissue Based on Biomaterials -- 7.8 Scaffolds for Cardiac Tissue Engineering -- 7.9 The Ideal Cell -- 7.10 Preparation of Cells for In-Vitro Tissue Engineering: Cell Permeable Cre/loxP System -- 7.11 Outlook -- References -- 8 Collagen Fabrication for the Cell-based Implants in Regenerative Medicine -- 8.1 Regenerative Medicine -- 8.2 The Cell-Based Implants -- 8.3 Requirements of Materials for the Cell-Based Implants -- 8.4 Biomaterials in the Cell-Hybridization -- 8.5 Characteristics of Collagen -- 8.6 Fabrication of Collagen -- 8.7 Collagen in the Cell-based Implants -- 8.8 Discussion -- References -- 9 Tissue Engineering - Combining Cells and Biomaterials into Functional Tissues -- 9.1 Introduction -- 9.2 The Cells -- 9.3 The Material -- References -- 10 Micro and Nano Patterning for Cell and Tissue Engineering -- 10.1 Overview -- 10.2 Regulation of Cell Functions by Matrix Patterning -- 10.3 Topographic Regulation of Cell Functions
  • 10.4 Engineering 3D Environments with Micro Features -- 10.5 Nano Patterning for Cell and Tissue Engineering -- 10.6 Perspective -- References -- 11 Integrative Nanobioengineering: Novel Bioelectronic Tools for Real Time Pharmaceutical High Content Screening in Living Cells and Tissues -- 11.1 Introduction -- 11.2 Real Time Monitoring and High Content Screening -- 11.3 Outlook and Future Aspects -- References -- Part IV Mechanics of Soft Tissues, Fluids and Molecules -- 12 Soft Materials in Technology and Biology - Characteristics, Properties, and Parameter Identification -- 12.1 Introduction -- 12.2 Material Description -- 12.3 Basics of Continuum Mechanics -- 12.4 Basics of Material Theory -- 12.5 Material Laws for Technical and Biological Polymers -- 12.6 Volume Change in Biopolymers -- 12.7 Summary and Outlook -- References -- 13 Modeling Cellular Adaptation to Mechanical Stress -- 13.1 Introduction -- 13.2 A Brief Review of Stretch-Induced Cell Remodeling -- 13.3 Measurements, Modeling, and Mechanotransduction -- 13.4 A New Approach for the Study of the Mechanobiology of Cell Stretching -- 13.5 Illustrative Examples -- 13.6 Closure -- References -- 14 How Strong is the Beating of Cardiac Myocytes? - The CellDrum Solution -- 14.1 Introduction -- 14.2 The Cell Drum Technique -- 14.3 Preparation of Samples -- References -- 15 Mechanical Homeostasis of Cardiovascular Tissue -- 15.1 Introduction -- 15.2 Shear Stress and Scaling Laws of Vascular System -- 15.3 Stress and Strain -- 15.4 Intramural Stress and Strain -- 15.5 Perturbation of Mechanical Homeostasis -- 15.6 Limitations, Implications and Future Directions -- References -- 16 The Role of Macromolecules in Stabilization and De-Stabilization of Biofluids -- 16.1 Introduction -- 16.2 The Effects of Macromolecules on the Stability of Colloids
  • 16.3 Macromolecular Depletion at Biological Interfaces -- 16.4 Cell-Cell Interactions Mediated by Macromolecular Depletion -- 16.5 Stabilization of Bio-Fluids via Macromolecules -- 16.6 Destabilization of Bio-Fluids via Macromolecular Binding -- 16.7 Conclusion & Outlook -- References -- 17 Hemoglobin Senses Body Temperature -- 17.1 Instead of an Introduction -- 17.2 Physiological Aspects of Thermoregulation in the Body -- 17.3 Red Blood Cells -- 17.4 Temperature Transition in RBC Passage Through Micropipettes -- 17.5 The Molecular Mechanism of the Micropipette Passage Transition -- 17.6 Hemoglobin Viscosity Transition -- 17.7 Circular Dichroism Transition in Diluted Hb Solutions -- 17.8 A RBC Volume Transition Revealed with Micropipette Studies -- 17.9 Micropipette Passage Transition in D2O Buffer -- 17.10 NMR T1 Relaxation Time Transition of RBCs in Autologous Plasma -- 17.11 Colloid Osmotic Pressure Transition of RBC Suspended in Plasma -- 17.12 The Temperature Transition Effect so Far -- 17.13 Strange coevals - Ornithorhynchus anatinus and Tachyglossus aculeatus -- 17.14 Hb Temperature Transition of Species with Body Temperatures Different from 37 ◦ C -- 17.15 Molecular Structural Mechanism of the Temperature Transitions -- 17.16 Physics Meets Physiology -- References -- Part V Bioengineering in Clinical Applications -- 18 Nitric Oxide in the Vascular System: Meet a Challenge -- 18.1 Nitric Oxide: NO -- 18.2 NO in Vascular Biology -- 18.3 Key Questions -- 18.4 Assessment of NO Mediated Vasoactivity -- 18.5 From the In-Vivo and Ex-Vivo Detection of NO Effects to Biochemical Assessment of NO -- 18.6 On the Road to a Potential Sensitive Marker for NO Formation: Is Nitrite a Candidate? -- 18.7 More Information About NO Interactions in the Blood -- 18.8 Intravascular Sources of NO -- 18.9 The Potential Relevance of RBC NOS Activity -- 18.10 Outlook
  • References -- 19 Vascular Endothelial Responses to Disturbed Flow: Pathologic Implications for Atherosclerosis -- 19.1 Introduction -- 19.2 Endothelial Dysfunction is a Marker of Atherosclerotic Risk -- 19.3 Correlation Between Lesion Locations and Disturbed Flow Regions of the Arterial Tree -- 19.4 In Vitro Studies on the Effects of Disturbed Flow on ECs -- 19.5 In Vivo Studies on the Effects of Disturbed Flow on ECs -- 19.6 Summary and Conclusions -- References -- 20 Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume -- 20.1 Introduction -- 20.2 Physiopathological Events During Sepsis -- 20.3 Markers in Clinical Diagnosis of Sepsis -- 20.4 Microcirculation and Sepsis -- 20.5 Therapy -- 20.6 Activated Protein C -- 20.7 Red Blood Cell Behaviour During Sepsis -- 20.8 New Perspective -- References -- 21 Bioengineering of Inflammation and Cell Activation: Autodigestion in Shock -- 21.1 Introduction -- 21.2 Inflammation in Shock and Multi-Organ Failure -- 21.3 The Pancreas as a Source of Cellular Activating Factors and the Role of Serine Proteases -- 21.4 Blockade on Pancreatic Digestive Enzymes in the Lumen of the Intestine -- 21.5 What Mechanisms Prevent Auto-digestion? -- 21.6 Triggers of Shock Increase Intestinal Wall Permeability -- 21.7 Intestine as Source of Inflammatory Mediators in Shock -- 21.8 Characterization of Protease-Derived Shock Factors -- 21.9 Cytotoxic Factors Derived from the Intestine -- 21.10 Removal or Blockade of Intestinal Cytotoxic Mediators -- 21.11 Conclusions -- References -- 22 Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications -- 22.1 Introduction -- 22.2 Vertebroplasty: Minimally Invasive and Cost-Effective Solution -- 22.3 Extravertebral Biomechanics: Excessive Delivery Pressure -- 22.4 Intravertebral Biomechanics: Risk of Extravasation
  • 22.5 Injectable Biomaterials
Control code
EBC364100
Extent
1 online resource (718 pages)
Form of item
online
Isbn
9783540754091
Media category
computer
Media MARC source
rdamedia
Media type code
c
System control number
  • (MiAaPQ)EBC364100
  • (Au-PeEL)EBL364100
  • (CaPaEBR)ebr10223696
  • (OCoLC)233973558
Label
Bioengineering in Cell and Tissue Research
Publication
Copyright
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • CONTENTS -- Part I Genes, Genome and Information Network -- 1 Reporter Genes in Cell Based ultra High Throughput Screening -- 1.1 Introduction -- 1.2 From Gene to Target -- 1.3 Screening Assay Classes -- 1.4 Reporter Gene Classes -- 1.5 Flash-Light Reporter Genes -- 1.6 Glow-Light Reporter Genes -- 1.7 Coelenterazine Dependent Luciferases -- 1.8 Luciferin Dependent Luciferases -- 1.9 Non-Luciferase Glow-Light Reporter Genes -- 1.10 Fluorescent Proteins -- 1.11 Cell Based Assay Formats in ultra High Throughput Screening (uHTS) -- 1.12 Reporter Genes in uHTS -- 1.13 Photoprotein Readouts and Cell-Based Assay Development -- 1.14 Multiplexing Reporter Gene Readouts -- 1.15 Ultra High Throughput Screening -- References -- 2 Gene Arrays for Gene Discovery -- 2.1 Introduction -- 2.2 Data Processing -- 2.3 Gene Discovery by Gene Clustering -- 2.4 TGF-β1 Signaling in Dendritic Cells Assessed by Gene Expression Profiling -- 2.5 Conclusions -- References -- 3 Physical Modulation of Cellular Information Networks -- 3.1 Introduction -- 3.2 Cellular Responses to Physical Stimulation -- 3.3 Electrically Controlled Proliferation Under Constant Potential Application -- 3.4 Modulated Proliferation Under Extreme Hydrostatic Pressure -- 3.5 Electrically Modulated Gene Expression Under Alternative Potential Application -- 3.6 Cellular Engineering to Enhance Responses to Physical Stimulation -- 3.7 Concluding Remarks -- References -- Part II Cell and Tissue Imaging -- 4 Fluorescence Live-Cell Imaging: Principles and Applications in Mechanobiology -- 4.1 Introduction -- 4.2 Fluorescence Proteins -- 4.3 Fluorescence Microscopy -- 4.4 Applications in Mechanobiology -- 4.5 Perspective in Cardiovascular Physiology and Diseases -- References -- 5 Optical Coherence Tomography (OCT) - An Emerging Technology for Three-Dimensional Imaging of Biological Tissues
  • 5.1 Introduction -- 5.2 Optical Coherence Tomography (OCT) -- 5.3 Applications in Tissue Engineering -- 5.4 Conclusion -- References -- 6 Ultrasonic Strain Imaging and Reconstructive Elastography for Biological Tissue -- 6.1 Introduction -- 6.2 Ultrasound Elastography -- 6.3 Reconstructive Ultrasound Elastography -- 6.4 Medical Results of Elastography -- 6.5 Results of an Intravascular Ultrasound Study -- 6.6 Summary and Conclusion -- References -- Part III Regenerative Medicine and Nanoengineering -- 7 Aspects of Embryonic Stem Cell Derived Somatic Cell Therapy of Degenerative Diseases -- 7.1 Introduction -- 7.2 Rationale for the Cardiac Tissue Engineering -- 7.3 Embryonic Stem Cells as an Unlimited Source for Cardiomyocytes -- 7.4 Therapeutical Cloning of Embryonic Stem Cells -- 7.5 Stem Cell Derived Cardiomyocytes -- 7.6 Cardiac Tissue Slices -- 7.7 Bioartificial Heart Tissue Based on Biomaterials -- 7.8 Scaffolds for Cardiac Tissue Engineering -- 7.9 The Ideal Cell -- 7.10 Preparation of Cells for In-Vitro Tissue Engineering: Cell Permeable Cre/loxP System -- 7.11 Outlook -- References -- 8 Collagen Fabrication for the Cell-based Implants in Regenerative Medicine -- 8.1 Regenerative Medicine -- 8.2 The Cell-Based Implants -- 8.3 Requirements of Materials for the Cell-Based Implants -- 8.4 Biomaterials in the Cell-Hybridization -- 8.5 Characteristics of Collagen -- 8.6 Fabrication of Collagen -- 8.7 Collagen in the Cell-based Implants -- 8.8 Discussion -- References -- 9 Tissue Engineering - Combining Cells and Biomaterials into Functional Tissues -- 9.1 Introduction -- 9.2 The Cells -- 9.3 The Material -- References -- 10 Micro and Nano Patterning for Cell and Tissue Engineering -- 10.1 Overview -- 10.2 Regulation of Cell Functions by Matrix Patterning -- 10.3 Topographic Regulation of Cell Functions
  • 10.4 Engineering 3D Environments with Micro Features -- 10.5 Nano Patterning for Cell and Tissue Engineering -- 10.6 Perspective -- References -- 11 Integrative Nanobioengineering: Novel Bioelectronic Tools for Real Time Pharmaceutical High Content Screening in Living Cells and Tissues -- 11.1 Introduction -- 11.2 Real Time Monitoring and High Content Screening -- 11.3 Outlook and Future Aspects -- References -- Part IV Mechanics of Soft Tissues, Fluids and Molecules -- 12 Soft Materials in Technology and Biology - Characteristics, Properties, and Parameter Identification -- 12.1 Introduction -- 12.2 Material Description -- 12.3 Basics of Continuum Mechanics -- 12.4 Basics of Material Theory -- 12.5 Material Laws for Technical and Biological Polymers -- 12.6 Volume Change in Biopolymers -- 12.7 Summary and Outlook -- References -- 13 Modeling Cellular Adaptation to Mechanical Stress -- 13.1 Introduction -- 13.2 A Brief Review of Stretch-Induced Cell Remodeling -- 13.3 Measurements, Modeling, and Mechanotransduction -- 13.4 A New Approach for the Study of the Mechanobiology of Cell Stretching -- 13.5 Illustrative Examples -- 13.6 Closure -- References -- 14 How Strong is the Beating of Cardiac Myocytes? - The CellDrum Solution -- 14.1 Introduction -- 14.2 The Cell Drum Technique -- 14.3 Preparation of Samples -- References -- 15 Mechanical Homeostasis of Cardiovascular Tissue -- 15.1 Introduction -- 15.2 Shear Stress and Scaling Laws of Vascular System -- 15.3 Stress and Strain -- 15.4 Intramural Stress and Strain -- 15.5 Perturbation of Mechanical Homeostasis -- 15.6 Limitations, Implications and Future Directions -- References -- 16 The Role of Macromolecules in Stabilization and De-Stabilization of Biofluids -- 16.1 Introduction -- 16.2 The Effects of Macromolecules on the Stability of Colloids
  • 16.3 Macromolecular Depletion at Biological Interfaces -- 16.4 Cell-Cell Interactions Mediated by Macromolecular Depletion -- 16.5 Stabilization of Bio-Fluids via Macromolecules -- 16.6 Destabilization of Bio-Fluids via Macromolecular Binding -- 16.7 Conclusion & Outlook -- References -- 17 Hemoglobin Senses Body Temperature -- 17.1 Instead of an Introduction -- 17.2 Physiological Aspects of Thermoregulation in the Body -- 17.3 Red Blood Cells -- 17.4 Temperature Transition in RBC Passage Through Micropipettes -- 17.5 The Molecular Mechanism of the Micropipette Passage Transition -- 17.6 Hemoglobin Viscosity Transition -- 17.7 Circular Dichroism Transition in Diluted Hb Solutions -- 17.8 A RBC Volume Transition Revealed with Micropipette Studies -- 17.9 Micropipette Passage Transition in D2O Buffer -- 17.10 NMR T1 Relaxation Time Transition of RBCs in Autologous Plasma -- 17.11 Colloid Osmotic Pressure Transition of RBC Suspended in Plasma -- 17.12 The Temperature Transition Effect so Far -- 17.13 Strange coevals - Ornithorhynchus anatinus and Tachyglossus aculeatus -- 17.14 Hb Temperature Transition of Species with Body Temperatures Different from 37 ◦ C -- 17.15 Molecular Structural Mechanism of the Temperature Transitions -- 17.16 Physics Meets Physiology -- References -- Part V Bioengineering in Clinical Applications -- 18 Nitric Oxide in the Vascular System: Meet a Challenge -- 18.1 Nitric Oxide: NO -- 18.2 NO in Vascular Biology -- 18.3 Key Questions -- 18.4 Assessment of NO Mediated Vasoactivity -- 18.5 From the In-Vivo and Ex-Vivo Detection of NO Effects to Biochemical Assessment of NO -- 18.6 On the Road to a Potential Sensitive Marker for NO Formation: Is Nitrite a Candidate? -- 18.7 More Information About NO Interactions in the Blood -- 18.8 Intravascular Sources of NO -- 18.9 The Potential Relevance of RBC NOS Activity -- 18.10 Outlook
  • References -- 19 Vascular Endothelial Responses to Disturbed Flow: Pathologic Implications for Atherosclerosis -- 19.1 Introduction -- 19.2 Endothelial Dysfunction is a Marker of Atherosclerotic Risk -- 19.3 Correlation Between Lesion Locations and Disturbed Flow Regions of the Arterial Tree -- 19.4 In Vitro Studies on the Effects of Disturbed Flow on ECs -- 19.5 In Vivo Studies on the Effects of Disturbed Flow on ECs -- 19.6 Summary and Conclusions -- References -- 20 Why is Sepsis an Ongoing Clinical Challenge? Lipopolysaccharide Effects on Red Blood Cell Volume -- 20.1 Introduction -- 20.2 Physiopathological Events During Sepsis -- 20.3 Markers in Clinical Diagnosis of Sepsis -- 20.4 Microcirculation and Sepsis -- 20.5 Therapy -- 20.6 Activated Protein C -- 20.7 Red Blood Cell Behaviour During Sepsis -- 20.8 New Perspective -- References -- 21 Bioengineering of Inflammation and Cell Activation: Autodigestion in Shock -- 21.1 Introduction -- 21.2 Inflammation in Shock and Multi-Organ Failure -- 21.3 The Pancreas as a Source of Cellular Activating Factors and the Role of Serine Proteases -- 21.4 Blockade on Pancreatic Digestive Enzymes in the Lumen of the Intestine -- 21.5 What Mechanisms Prevent Auto-digestion? -- 21.6 Triggers of Shock Increase Intestinal Wall Permeability -- 21.7 Intestine as Source of Inflammatory Mediators in Shock -- 21.8 Characterization of Protease-Derived Shock Factors -- 21.9 Cytotoxic Factors Derived from the Intestine -- 21.10 Removal or Blockade of Intestinal Cytotoxic Mediators -- 21.11 Conclusions -- References -- 22 Percutaneous Vertebroplasty: A Review of Two Intraoperative Complications -- 22.1 Introduction -- 22.2 Vertebroplasty: Minimally Invasive and Cost-Effective Solution -- 22.3 Extravertebral Biomechanics: Excessive Delivery Pressure -- 22.4 Intravertebral Biomechanics: Risk of Extravasation
  • 22.5 Injectable Biomaterials
Control code
EBC364100
Extent
1 online resource (718 pages)
Form of item
online
Isbn
9783540754091
Media category
computer
Media MARC source
rdamedia
Media type code
c
System control number
  • (MiAaPQ)EBC364100
  • (Au-PeEL)EBL364100
  • (CaPaEBR)ebr10223696
  • (OCoLC)233973558

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